intro

The Biomolecular Simulation and Computational Chemistry Group at ICRM-CNR, headed by Dr. Giorgio Colombo, focusses on the dynamic simulation of biomolecular systems and on the investigation of molecular recognition.

The fundamental questions we are trying to answer are:

. What are the sequence and structural determinants of protein stability and functional  dynamics?
. What are the fundamentals of ligand binding, allostery and protein-protein interactions?
. What makes certain proteins misfold and aggregate into toxic oligomers associated with neurodegenerative diseases?
. How can we translate this knowledge in the design of new and better candidate drugs and vaccines?

For more information about our group please contact us


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